Zooanthroponotic transmission of SARS-CoV-2 and host-specific viral mutations revealed by genome-wide phylogenetic analysisArticle Published on 2023-04-042023-06-22 Journal: eLife [Category] 조류인플루엔자, [키워드] Evolutionary biology Genome-wide association study Genomic epidemiology Phylogeny SARS-CoV-2 viral evolution viruses zooanthroponosis. [DOI] 10.7554/eLife.83685 PMC 바로가기
Adjudicating the logistics of COVID-19 vaccine boosters from a global perspective글로벌 관점에서 COVID-19 백신 부스터의 물류 판단Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, [키워드] booster booster vaccination booster vaccinations COVID-19 COVID-19 vaccination COVID-19 vaccine Effectiveness equity Immune escape Immune-mediated immunocompromised individuals implementation indicate Perspective Premature protective immunity protocol response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Side effects vaccination Vaccine Vaccine hesitancy vaccine. variant viral evolution waning immunity weighed [DOI] 10.1080/21645515.2021.2020572 PMC 바로가기 [Article Type] Article
Viro-immunological evaluation in an immunocompromised patient with long-lasting SARS-CoV-2 infection오래 지속되는 SARS-CoV-2 감염이 있는 면역 저하 환자의 바이러스 면역학적 평가Article Published on 2022-12-012022-09-12 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, [키워드] Abstract IFN-γ Immunocompromised patient Immunosuppression long-lasting SARS-CoV-2 SARS-COV-2 infection Seroconversion viral evolution viral evolution. [DOI] 10.1080/22221751.2022.2045877 PMC 바로가기 [Article Type] Article
Geographical distribution of SARS-CoV-2 amino acids mutations and the concomitant evolution of seven distinct clades in non-human hostsArticle Published on 2022-11-012022-11-16 Journal: Zoonoses and Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid analysed Analysis antigenicity clade Combination country Denmark distribution early stage Efficacy epidemiological Evolution exhibiting GISAID globe Host human SARS-CoV-2 indicate Latvia Local moderate MOST Mutation mutations Netherlands Non-human Non-human hosts ORF10 ORF3a pandemic pathogenicity Proteome evolution raised SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2. sequence Seven Surveillance sustained the SARS-CoV-2 genome the vaccine Transmissibility transmissions USA variant viral evolution Viral transmission viral variant Whole-genome sequence zoonotic zoonotic transmission [DOI] 10.1111/zph.12971 PMC 바로가기
Antibody response and intra-host viral evolution after plasma therapy in COVID-19 patients pre-exposed or not to B-cell-depleting agentsArticle Published on 2022-11-012022-11-15 Journal: British Journal of Haematology [Category] SARS, 진단, [키워드] anti-CD20 anti-CD20 therapy Anti-spike anti-Spike IgG antibody antibody kinetics B-cell clinical care clinical status clinical symptom Complete contribute convalescent convalescent plasma COVID-19 patient Decline donors eligible evaluated Follow-up hospitalized COVID-19 patients humoral Humoral immunity IgG Immune escape Immunocompromised Immunocompromised patients Immunoglobulin impair lymphopenia majority management mRNA-based vaccine mRNA-based vaccine plasma mutation rate Patient patients treated plasma receiving SARS-CoV-2 SARS-CoV-2 viral load SARS-CoV-2-specific antibodies severity spike mutations survival therapy titre viral control viral evolution virus clearance WHO whole-genome sequencing Whole-genome sequencing. World Health Organization [DOI] 10.1111/bjh.18450 PMC 바로가기
Breakthrough Gastrointestinal COVID-19 and Intrahost Evolution Consequent to Combination Monoclonal Antibody ProphylaxisArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] amino acid change antiviral therapy Breakthrough infection Colon Consequent COVID-19 Deletion furin cleavage site Gastrointestinal gastrointestinal tract Infection intestinal low-dose monoclonal antibody mucosa mucosal nonhuman primates promote Prophylaxis rectal swab Replication rhesus SARS-CoV-2 suboptimal prophylaxis. tissue upper respiratory viral evolution viral replication Viral RNA virus virus stock [DOI] 10.1093/infdis/jiac134 PMC 바로가기
[Vaccination against coronavirus disease 2019 (COVID-19)]Article Published on 2022-11-012022-11-15 Journal: Zeitschrift Fur Gerontologie Und Geriatrie [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome adenoviral vector vaccine Adults age antibodies, neutralizing approval booster vaccination Clinical efficacy Concentration coronavirus coronavirus disease Course declined English Europe groups heterogeneous Hospitalization immunogenicity immunogenicity, vaccine increase Infection mRNA vaccines National neutralizing antibody New Older omicron original virus strain Patient recommendation recommendations reduced risk Risk factors SARS-CoV‑2 SARS-CoV‑2 variants severe disease tested Trial Vaccination recommendations. Vaccinations Vaccine vaccine dose Vaccines variant viral evolution virus variant virus variants [DOI] 10.1007/s00391-022-02102-x PMC 바로가기
Insertion/deletion hotspots in the Nsp2, Nsp3, S1, and ORF8 genes of SARS-related coronavirusesArticle Published on 2022-10-282022-11-16 Journal: BMC Ecology and Evolution [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome animal hosts base bases bat bat coronavirus benefit Characteristics classical complex coronavirus determine Frame Future Genome genomic region hotspot Human human SARS-CoV-2 human SARS-CoV-2 strain INDEL Indel hotspot indels insertion/deletion insertion/deletion (indel). mechanism Multiple sequence alignment Mutation N-terminal domain Neutral non-structural protein Occurrence offer ORF8 ORF8 gene pangolin Pangolin coronavirus (PCoV) Point mutation RaTG13 Region reported RNA sequence S1 domain SARS-CoV SARS-CoV-2 SARS-related coronavirus SARS-related coronaviruses severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) survival the spike protein viral evolution virus virus viruses [DOI] 10.1186/s12862-022-02078-7 PMC 바로가기
SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial CellsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] Activation Adaptive immune response association biochemical Caco2 caused changed chemokine Colon contributed COVID-19 cytokine declining Delta delta variant disease epithelial cell line evade Evolution expected fatality feature highlighting Host Human humans IFN IFN response Infection Innate innate antiviral innate immune response interferon Intervention mechanism multiple mechanism outcome pandemic pathophysiology pathway persistence receptor reduced Replication response resulting RLR pathway robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severe infection severe symptom silent susceptible sustained the disease transcriptomic Treatment vaccination variant variants variants. viral evolution virulence virus with COVID-19 [DOI] 10.1128/spectrum.01604-22 PMC 바로가기
Time Series Analysis of SARS-CoV-2 Genomes and Correlations among Highly Prevalent MutationsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis arising caused characterized Cluster Clustering computational tool contribute coronavirus correlated correlation correlation coefficient COVID-19 Deleterious Effect effort Evolution Frequency Genome genomes Hierarchical hierarchical clustering identify imperative in viral Meta-analysis Mutation mutations negative correlation Neutral NSP2 Nsp3 nucleotide ORF3a protein P323L pandemic Pearson Pearson correlation performed positive Protein protein dynamics. Q57H RdRP replaced RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 isolate SARS-CoV-2 sequences Scientific community Sery shown similarity stabilizing effect statistical T85I These data time UTR viral evolution viral genomes viral pathogenesis viral replication viral strains wild type wild-type [DOI] 10.1128/spectrum.01219-22 PMC 바로가기